In mathematics, an orientation of a curve is the choice of one of the two possible directions for travelling on the curve. For example, for Cartesian coordinates, the x-axis is traditionally oriented toward the right, and the y-axis is upward oriented.

In the case of a planar simple closed curve (that is, a curve in the plane whose starting point is also the end point and which has no other self-intersections), the curve is said to be positively oriented or counterclockwise oriented, if one always has the curve interior to the left (and consequently, the curve exterior to the right), when traveling on it. Otherwise, that is if left and right are exchanged, the curve is negatively oriented or clockwise oriented. This definition relies on the fact that every simple closed curve admits a well-defined interior, which follows from the Jordan curve theorem.

The inner loop of a beltway road in a country where people drive on the right side of the road is an example of a negatively oriented (clockwise) curve. In trigonometry, the unit circle is traditionally oriented counterclockwise.

The concept of orientation of a curve is just a particular case of the notion of orientation of a manifold (that is, besides orientation of a curve one may also speak of orientation of a surface, hypersurface, etc.).